Steroizii si tendoanele... [Archive] - FITNESS . NUTRITIE . ANTRENAMENT . CULTURISM . SUPLIMENTE NUTRITIVE . SCADERE IN GREUTATE

slick

22-12-2003, 23:41

Am postat acum vreo saptamana acest subiect dar nu cred ca l-ati primit. Daca va uitati la profilul meu, search all posts by this user, veti vedea ca apare subiectul dar nu se poate accesa caci este un invalid link! Strange! :confused:
Iata cum suna:

As vrea sa stiu daca testosteronul are un efect pozitiv asupra tendoanelor sau ligamentelor; citeam mai demult pe un site cu experiente de utilizare a steroizilor, ca unele persoane care sufereau de tot felul de dureri de umeri, spate etc datorate unor accidentari mai vechi, cand au inceput sa foloseasca steroizi(era un site american deci sub 500mg pe saptamana nu se discuta, 3-4 tipuri diferite de steroizi etc) durerile le-au trecut... asta pe langa better recovery, increase muscule mass, strenght, better mood etc.
Cu alte cuvinte, eu am o durere la umarul stang, o sechela, cand trosneste doare de la o accidentare mai veche si daca o sa fac un ciclu de 8 saptamani cu 250mg de Sustanol pe saptamana, sunt sanse sa nu mai ma deranjeze umarul in timpul ciclului? Intreb din curiozitate, va mai trece ceva timp pana si daca voi folosi steroizi.
Multumesc.

Dr.S.Damian

23-12-2003, 00:30

Am primit si primul tau mesaj si ma pregateam sa raspund. Am avut unele restante in ultima vreme si imi cer scuze.

In privinta problemei tale pot sa iti spun ca din cate am citit eu, steroizii (nu toti, in special nu testosteronul) au efecte pozitive asupra reconstructiei structurilor colagenice. Pe de alta parte, abuzul conduce la efectul invers (distrugerea structurii cu slabiciune ulterioara).

Uite un articol care o sa te lamureasca mai bine:

Title: Stimulation of collagen synthesis by the anabolic steroid stanozolol.

Researchers: Falanga V, Greenberg AS, Zhou L, Ochoa SM, Roberts AB, Falabella A, Yamaguchi Y; University of Miami School of Medicine, Department of Dermatology, Miami, Veterans Affairs Medical Center, Florida, USA.

Source: J Invest Dermatol 1998 Dec;111(6):1193-7

Summary: In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 micrograms per ml) had no effect on fibroblast replication and cell viability but enhanced collagen synthesis in a dose-dependent manner. Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels. There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta-1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta-1. These findings point to a novel mechanism of action of anabolic steroids.

Discussion: I must first acknowledge that the commonly held belief is that anabolic steroids predispose an athlete to tendon rupture. This conclusion is drawn from animal studies showing that some steroids produce a larger, stiffer tendon in rats and that these steroid-induced tendons "fail" before the tendons from the control animals. The term fail refers to the breaking point.

The interesting thing about the present study is that the steroid stanozolol (Winstrol) had a different effect than testosterone.

Because synthetic steroids have differ in their chemical properties it should not be surprising that testosterone did not have the same effect as Winstrol. Winstrol increased collagen synthesis as opposed to testosterone which did not in this study. Interpreting the results of this study are more difficult than simply describing them. Other researchers have suggested that steroids cause a rapid increase in protein synthesis within tendon fibroblasts which results in fibroids or fibrous nodules within the tendon (Michna,1988). These fibroids alter the mechanical properties of the tendon perhaps predisposing it to rupture. It is also noted that during short term use of steroids there is an alteration in the alignment of collagen fibers which may also lead to rupture. Interestingly these alterations in collagen metabolism are transient with markers of collagen turnover returning more or less to baseline after 3-4 weeks of steroid administration (Karpakka,1992). These same researchers noted that low dose anabolics effect primarily muscle collagenous tissue with tendon being effected only at higher doses (i.e. 5 times the therapeutic dose) which would more closely represent what is needed by bodybuilders to put on mass.

The question remains, dose this mean that Winstrol will actually help prevent tendon injury or will it lead to bigger yet stiffer tendons prone to injury? It is difficult to take animal research and extrapolate the results to humans. Stanozolol is used therapeutically in humans to treat a variety of connective tissue and vascular disorders and its clinical effects suggest that it can modulate connective tissue breakdown in people. Despite being labeled as "ineffective" by many bodybuilders it is very popular among athletes. As with most hormones, dosage plays a role in what effects are seen, be they positive or negative. Hopefully future studies will shed light on the therapeutic effects of different steroids on tendons in humans.

References:

Michna H Appearance and ultrastructure of intranuclear crystalloids in tendon fibroblasts induced by an anabolic steroid hormone in the mouse. Acta Anat (Basel) 1988;133(3):247-50

Karpakka JA, Pesola MK, Takala TE. The effects of anabolic steroids on collagen synthesis in rat skeletal muscle and tendon. A preliminary report. Am J Sports Med 1992 May-Jun;20(3):262-6